Exponential Fitting of Postextrasystolic Potentiation May Underestimate the Cardiac Ca2+ Recirculation Fraction: A Theoretical Analysis
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چکیده
منابع مشابه
Exponential fitting of postextrasystolic potentiation may underestimate the cardiac Ca2+ recirculation fraction: a theoretical analysis.
The recirculation fraction of intramyocardial Ca(2+) (RF) has conventionally been obtained from the monotonic decay of postextrasystolic potentiation (PESP). The used assumption is that the decay is exponential. However, we have found that PESP usually decays in alternans even at spontaneous heart rates (>100 beats/min) in excised, cross-circulated canine heart preparations under normal coronar...
متن کاملTemperature-dependent postextrasystolic potentiation and Ca recirculation fraction in canine hearts
JU MIZUNO,1,2 JUNICHI ARAKI,1 SHUNSUKE SUZUKI,2 SATOSHI MOHRI,1,3 TAKESHI MIKANE,2 JUICHIRO SHIMIZU,1 HIROMI MATSUBARA,3 MASAHISA HIRAKAWA,2 TOHRU OHE,3 AND HIROYUKI SUGA1,4 Departments of 1Cardiovascular Physiology, 2Anesthesiology and Resuscitology, and 3Cardiovascular Medicine, Okayama University Graduate School of Medicine and Dentistry, Okayama, 700-8558; and 4National Cardiovascular Cente...
متن کاملTemperature-dependent postextrasystolic potentiation and Ca(2+) recirculation fraction in canine hearts.
We have found that cardiac temperature proportionally changes O(2) cost of contractility, defined as O(2) consumption for myocardial total Ca(2+) handling normalized to contractility in terms of the end-systolic pressure-volume ratio (maximal elastance, E(max)), in the canine left ventricle (temperature sensitivity, Q(10) = 2). We have separately found that a decrease in the recirculation fract...
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BACKGROUND Postextrasystolic blood pressure potentiation (PESP), the pulse wave augmentation after an extrasystolic beat, is typically enhanced in heart failure (HF) patients. This study prospectively tested the association of PESP and mortality in cardiac patients. METHODS AND RESULTS Consecutive patients (n=941; mean age, 61 years; 19% female) presenting with acute myocardial infarction wer...
متن کاملPostextrasystolic Potentiation and Echocardiography
The purpose of this study was to determine whether echocardiography can be used to monitor postextrasystolic potentiation (PESP) and, if so, which of the echocardiographic variables are valid indicators of PESP and under what conditions. An implantable M-mode echocardiographic transducer was sewn to the right ventricular outflow tract of the dog heart to record continuously across the minor dia...
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ژورنال
عنوان ژورنال: The Japanese Journal of Physiology
سال: 2003
ISSN: 0021-521X
DOI: 10.2170/jjphysiol.53.89